徐格林



徐格林


教授,主任医师
办公室电话:025-80863531
Email:gelinxu@nju.edu.cn


研究方向

1.脑血管病  2.血管内介入技术

个人简介

医学博士,南京军区南京总医院神经内科副主任,南京大学医学院教授,南京军区南京总医院神经病学研究所(暨南京大学神经病学研究所)副所长,主任医师,教授,博士研究生导师。1993年毕业于第四军医大学航空航天医学专业。目前主要从事动脉粥样硬化、脑血管病临床流行病学和神经血管介入等方面的研究工作。2013年起担任GBDGlobal Burden of Diseases)专家。目前担任英文期刊Interventional Neurology (Karger出版,Medline收录)副主编。担任SCI杂志BioMed Research InternationalSCI影响因子2.88)编委。针对脑血管病、神经损伤修复、动脉粥样硬化等临床常见问题展开研究。任现职以来,获得国家自然科学基金2项,江苏省自然科学基金3项,南京军区重点科研基金1项。作为子课题负责人,参与一项国家科技支撑计划,作为子课题负责人,参加江苏省临床中心建设。2011年以来,以第一作者或通讯作者身份发表SCI论文24篇。

科研成果
文章:

[1]. Cao L, Zhang Z, Cai B, Bai W, Zhang Y, Sun W, Xie X, Sun W, Cai Q, Li Z, Liu D, Xiong Y, Ma M, Liu X, Xu G(通讯作者). Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke. J Neurol Sci. 2014 Jun 29. pii: S0022-510X(14)00416-X. doi:10.1016/j.jns.2014.06.046. [Epub ahead of print] PubMed PMID: 25016572.

[2]. Cao L, Zhang Z, Sun W, Bai W, Sun W, Zhang Y, Wang X, Cai B, Xie X, Duan Z, Cai Q, Liu D, Xiong Y, Ma M, Liu X, Xu G(通讯作者). Impacts of COX-1 gene polymorphisms on vascular outcomes in patients with ischemic stroke and treated with aspirin. Gene. 2014 Jun 12. pii: S0378-1119(14)00687-8. doi: 10.1016/j.gene.2014.06.023. 

[3]. Zhang Z, Xu G(等同第一作者), Yang F, Zhu W, Liu X. Quantitative analysis of dietary protein intake and stroke risk. Neurology. 2014 Jun 11. pii:10.1212/WNL.0000000000000551.SCI IF=8.5

[4]. Xu G, Ma M, Liu X, Hankey GJ. Is there a stroke belt in china and why? Stroke. 2013 Jul;44(7):1775-83.  (SCI IF=6.158)

[5]. Li Y, Sun W, Yin Q, Wang Y, Cai Q, Sun W, Huang Z, Liu W, Xiong Y, Xu G(通讯作者), Liu X. Safety and efficacy of simultaneous bilateral carotid angioplasty and stenting. J Thromb Thrombolysis. 2013 Apr 4. [Epub ahead of print] PubMed PMID: 23553247. (SCI IF=1.985)  

[6]. Jiang Y, Zhu W, Zhu J, Wu L, Xu G(通讯作者), Liu X. Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of lesion artery in patients with stroke in the territory of middle cerebral artery. Cell Transplant. 2013;22(12):2291-8. (SCI IF=4.422) 

[7]. Zhang Z, Xu G (等同第一作者), Liu X. Chocolate intake reduces risk of cardiovascular disease: Evidence from 10 observational studies. Int J Cardiol. 2013 Oct 15;168(6):5448-50. (SCI IF=5.509)  

[8]. Wang X, Zhang Z, Liu W, Xiong Y, Sun W, Huang X, Jiang Y, Ni G, Sun W, Zhou L, Wu L, Zhu W, Li H, Liu X, Xu G(通讯作者). Impacts and interactions of PDGFRB, MMP-3, TIMP-2, and RNF213 polymorphisms on the risk of Moyamoya disease in Han Chinese human subjects. Gene. 2013 Sep 10;526(2):437-42. (SCI IF=2.196)  

[9]. Zhang Z, Xu G(等同第一作者), Ma M, Yang J, Liu X. Dietary Fiber Intake Reduces Risk for Gastric Cancer: A Meta-analysis. Gastroenterology. 2013 Jul;145(1):113-120.e3. (SCI IF=12.821) 

[10]. Zhang Z, Xu G(等同第一作者), Liu D, Fan X, Zhu W, Liu X. Angiotensin-converting enzyme insertion/deletion polymorphism contributes to ischemic stroke risk: a meta-analysis of 50 case-control studies. PLoS One. 2012;7(10):e46495. (SCI IF=3.73) 

[11]. Gong X, Ma M, Fan X, Li M, Liu Q, Liu X, Xu G(通讯作者). Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia. Neurosci Lett. 2012;513(1):20-4. (SCI IF=2.026)

[12]. Tian L, Guo R, Yue X, Lv Q, Ye X, Wang Z, Chen Z, Wu B, Xu G(通讯作者), Liu X. Intranasal administration of nerve growth factor ameliorate β-amyloid deposition after traumatic brain injury in rats. Brain Res. Brain Res. 2012;1440:47-55. (SCI IF=2.935)  

[13]. Liu W, Xu G, Yue X, Wang X, Ma M, Zhang R, Wang H, Zhou C, Liu X. Hyperintense vessels on FLAIR: A useful non-invasive method for assessing intracerebral collaterals. Eur J Radiol. 2011;80(3):786-791. (SCI IF=2.512)  

[14]. Xu G, Zhao W, Zheng L, Fan X, Yin Q, Liu X. Decreasing radiation doses in digital subtraction angiographies consecutively performed by trainees. Radiation Protection Dosimetry 2012,148(2)181-184. (SCI IF=0.909)

[15]. Zhu J, Jiang Y, Wu L, Lu T, Xu G(通讯作者), Liu X. Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia. Neuroscience. 2012;202:342-351. (SCI IF=3.122) 

[16]. Ni G, Liu W, Huang X, Zhu S, Yue X, Chen Z, Chen M, Liu X, Xu G(通讯作者). Increased levels of circulating SDF-1α and CD34+ CXCR4+ cells in patients with moyamoya disease. Eur J Neurol. 2011;18(11):1304-1309. (SCI IF=4.162)

[17]. Jiang Y, Wei N, Zhu J, Lu T, Chen Z, Xu G(通讯作者), Liu X. Effects of Brain-derived Neurotrophic Factor on Local Inflammation in Experimental Stroke of Rat. Mediators Inflamm. 2010; 2010:372423. (SCI IF=3.882) 

[18]. Xu G, Yin Q, Liu X. Narrowing the gap of stroke management between developed and developing countries. Cerebrovasc Dis. 2010;29(1):101-102. (SCI IF=2.814) 

[19]. Chen Z, Lu T, Yue X, Wei N, Jiang Y, Chen M, Ni G, Liu X, Xu G(通讯作者). Neuroprotective effect of ginsenoside Rb1 on glutamate-induced neurotoxicity: with emphasis on autophagy. Neurosci Lett. 2010 4;482(3):264-268. (SCI IF=2.026) 

[20]. Xu G, Zhao W, Zhou Z, Zhang R, Zhu W, Liu X. Danshen extracts decrease blood C reactive protein and prevent ischemic stroke recurrence: a controlled pilot study. Phytother Res. 2009;23(12):1721-1725. (SCI IF=2.068)  

[21]. Xu G, Zhou Z, Zhu W, Fan X, Liu X. Plasma C-reactive protein is related to cognitive deterioration and dementia in patients with mild cognitive impairment. J Neurol Sci. 2009;284(1-2):77-80.  (SCI IF=2.243)

[22]. Xu G, Liu X, Yin Q, Zhu W, Zhang R, Fan X. Alcohol consumption and transition of mild cognitive impairment to dementia. Psychiatry Clin Neurosci. 2009;63(1):43-49. (SCI IF=2.04)

[23]. Xu G, Zheng L, Zhou Z, Liu X. Stenting for a symptomatic posterior cerebral artery stenosis. Catheter Cardiovasc Interv. 2009;73(6):745-748. (SCI IF=2.514)  

[24]. Xu G, Liu X, Zheng L, Fan X, Yin Q. Successful recanalization of a chronic in-stent occlusion at the vertebral artery ostium. Interventional Neuroradiology. 2009;15: 462-465. (SCI IF=0.773) 

[25]. Xu G, Cheng S, Liu X. Focus on endovascular solutions for cerebrovascular diseases. Cerebrovasc Dis. 2008;26(6):667-668. (SCI IF=2.814)

[26]. Xu G, Zhang H, Zhang S, Fan X, Liu X. Plasma fibrinogen is associated with cognitive decline and risk for dementia in patients with mild cognitive impairment. Int J Clin Pract. 2008;62(7):1070-1075.  (SCI IF=2.427) 

[27]. Xu G. Building a Platform for East-West Communication in Stroke Research. Cerebrovasc Dis, 2008;25(3):279-280. (SCI IF=2.814) 

[28]. Xu G, Liu X. Impacts of population aging on the subtypes of stroke. Stroke. 2008 Jul;39(7):e102-105. (SCI IF=6.158)

[29]. Xu G, Liu X, Zhu W, Yin Q, Zhang R, Fan X. Feasibility of treating hyperfibrinogenemia with intermittently administered batroxobin in patients with ischemic stroke/transient ischemic attack for secondary prevention. Blood Coagul Fibrinolysis. 2007;18(2):193-197. (SCI IF=1.248)

[30]. Xu G, Liu X, Meyer JS, Yin Q, Zhang R. Cognitive performance after carotid angioplasty and stenting with brain protection devices. Neurol Res. 2007;29(3):251-255.        (SCI IF=1.182)

[31]. Xu G, Liu X, Wu W, Zhang R, Yin Q. Recurrence after ischemic stroke in chinese patients: impact of uncontrolled modifiable risk factors. Cerebrovasc Dis.

 

专利:

[1].  刘新峰, 姜永军, 徐格林. 双鼻腔持续经鼻给药装置及其使用方法. 中华人民共和国国家知识产权局, CN201010521697.9, 中国, 2010/10/27 (中国知识产权网). 专利.

[2].  刘新峰, 姜永军, 徐格林. 双鼻腔持续经鼻给药装置. 中华人民共和国国家知识产权局, CN201020579232.4, 中国, 2010/10/27 (中国知识产权网). 专利.

[3].  刘新峰, 徐格林, 岳炫烨. 远端血栓保护与血管成形球囊一体化装置. 中华人民共和国国家知识产权局, CN201020505520.5, 中国, 2010/8/25 (中国知识产权网). 专利.

[4].  刘新峰, 徐格林, 岳炫烨. 双腔血管鞘. CN201020284161.5, 2010/8/6 (中国知识产权网). 专利.


专著:

[1].  刘新峰,徐格林(副主编),张仁良。《脑血管病介入治疗学》,人民卫生出版社,北京,20068月。

[2].  刘新峰,徐格林(副主编),张仁良,殷勤,岳炫烨,周志明。《脑血管造影与颈动脉支架置入术》,中华医学电子音像出版社,北京,20097月。

[3].  刘新峰,徐格林(主编)。《脑血管病的血管内治疗——从指南到实践》,北京医科大学出版社,北京,2011年。

[4].  王拥军主编。徐格林(编委)。《脑血管病临床实践新理念》。人民军医出版社。北京,2012年。


获奖情况:

[1].刘新峰,刘国庆,梁慧康,徐格林,史兆荣,樊新颖,朱武生,马敏敏,殷勤,张仁良。脑梗死血管学特征谱的新发现与血运重建治疗的新策略。国家科学技术进步奖二等奖,2014年。

  

[2].刘新峰,刘国庆,梁慧康,马敏敏,朱武生,徐格林,张仁良,刘文华,孙芳,李芸,殷勤。脑梗死血运重建的新策略及其机理研究。江苏省科学技术奖一等奖,2013年。

  

[3].刘新峰,徐格林,殷勤,樊新颖,杨昉,刘玲,郭芮兵,李敏,刘德志,许剑,葛颂,周广怡,周志明,朱双根,张仁良,樊小兵,马敏敏,朱武生。脑卒中血管学病因及干预研究。高等学校科学研究优秀成果科技进步一等奖,2011年。

  

[4].徐格林,殷勤,张仁良。颅内Willis环以外动脉狭窄的支架治疗。江苏省卫生厅医学新技术引进奖一等奖,2009年。

  

[5].刘新峰,徐格林,易学明,张仁良,樊新颖,樊小兵,殷勤,朱武生,郭芮兵。经鼻给予多肽生长因子救治神经毒剂和脑缺血所致的脑损伤。军队科技进步一等奖,2009年。

  

[6].刘新峰,张仁良,徐格林,樊小兵,殷勤,朱武生,樊新颖,刘亚红,陈光辉。基于卒中登记的脑血管病系列研究。军队医疗成果二等奖,2008年。

  

[7].刘新峰,徐格林,朱武生,殷勤,张仁良,樊小兵,杨昉,刘亚红,陈光辉。缺血性脑血管病颅内、外动脉狭窄的诊断和介入治疗。军队医疗成果二等奖,2006年。