Christopher J. Butch


Christopher J. Butch

Associate Professor


University of South Carolina, Columbia, SC; Chemical Engineering; B.S.E., 2008
Georgia Institute of Technology, Atlanta, GA; Chemical Engineering; Ph.D., 2014
Tokyo Institute of Technology, Tokyo, JP; Earth Life Science Institute; Research Fellow, 2015–2018


Georgia Tech Dept. of Chem. and Biochem. Eng. Best Thesis (2014)
ELSI Origins Network (EON) Postdoctoral Fellowship (2015)
Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship (2017)

1. Su, G; Yang, S; Ren, J; Butch, C; Filimonov, S; Li, S; Liu, W; Switchable Schottky contacts: Simultaneous
enhanced output current and reduced leakage current, In Prep 2018
2. Butch, CJ; Cleaves, H; Meringer, M; The Small Organic Molecule Space of the Universe In Prep
Submitting to Angewandte 6/10/18
3. Butch, CJ; Cleaves, H; Burger, P; Goodwin, J; Meringer, M; One in a Million: The Chemical Space
of Nucleic Acid-like Molecules In Prep Submitting to PNAS 6/10/18
4. Kaiser, T; Burger, P; Butch, CJ; Pelly, S; Liotta, DC; A Machine Learning Approach for Predicting
HIV Reverse Transcriptase Mutation Susceptibility of Biologically Active Compounds, Journal of
Chemical Information and Modeling, Submitted 2018
5. Nguyen, HH; Kim, MB; Butch, CJ; Kuo, KM; Tahirovic, YA; Jecs, E; Wilson, RR; Miller, EJ; Truax,
VM; Wang, T; Sum, C; Chen, J; Cviic, ME; Shen, DR; Burford, N; Chen, C; Zhang, H; Tebben,
AJ; Schroeder, GM;Wilson, LJ; Liotta, DC; Design of Second-Generation Tetrahydroisoquinoline-
Based CXCR4 Antagonists with Favorable in Vitro ADME Properties, Journal of Medicinal Chemistry,
In Press 2018
6. Chandru, K; Guttenberg, N; Giri, C; Hongo, Y; Butch, C; McKenna, A; Mamajanov, I; Cleaves, H;
Simple prebiotic synthesis of high diversity dynamic combinatorial polyester libraries, Communications
Chemistry, 2018
7. Strong, K; Epplin, M; Basca, J; Butch, CJ; Burger, P; Traynelis, S; Liotta, DC; The Structure Activity
Relationship of a Tetrahydroisoquinoline Class of N-Methyl-D-Aspartate Receptor Modulators
that Potentiates GluN2B-Containing N-Methyl-D-Aspartate Receptors, Journal of Medicinal
Chemistry, 2017
8. Guttenberg, N; Virgo, N; Butch, CJ; Packard, N; Selection First Path to the Origin of Life, arXiv
preprint, 2017
9. Mohammed, F; Chen, K; Mojica, M; Conley, M; Napoline, J; Butch, CJ; Pollet, P; Krishnamurthy, R;
Liotta, CL; A Plausible Prebiotic Origin of Glyoxylate: Non-Enzymatic Transamination Reactions
of Glycine with Formaldehyde, Synlett, 2017
10. Chandru, K; Gilbert, A; Butch, CJ; Aono, M; Cleaves, H; The Abiotic Chemistry of Thiolated Acetate
Derivatives and the Origin of Life, Scientific Reports, 2016
11. Butch CJ; Wang J; Gu J; Vindas R; Crowe J; Pollet P; Gelbaum L; Leszczynski J; Krishnamurthy R;
Liotta CL. pH Controlled Reaction Divergence of Decarboxylation versus Fragmentation in Reactions
of Dihydroxyfumarate with Glyoxylate and Formaldehyde: Parallels to Biological Pathways.
Journal of Physical Organic Chemistry, 2016.
12. Scharf, Caleb; et al. A Strategy for Origins of Life Research. Astrobiology (2015).
13. Butch, CJ; Cope, ED; Pollet, PL; Gelbaum, L; Krishnamurthy, R; & Liotta, CL (2013). Production
of Tartrates by Cyanide Mediated Dimerization of Glyoxylate: A Potential Abiotic Pathway to the
Citric Acid Cycle. Journal of the American Chemical Society, 2013