| Research areas: Application of digital fluorescence imaging surgical navigation technology to clinical medicine including the design and optimization of core device components and the design, compounding and application of new-type fluorescent developer; The design, compounding and application of new mechanism of nano-tumor chemotherapy drugs including design and characterization of new mechanism drugs, mechanism exploration, drugability evaluation, and new drug declaration; The design, compounding and evaluation of new-type anti-HBV small molecule drugs including design and compounding of new-type drugs, drugability evaluation, and new drug declaration; The design, production and application of new-type medical magnetic nanoparticles including design, modification, metabolic characteristics, mechanism and application of new medical magnetic nanoparticles. Courses: PBL (Problem Based Learning), English Writing Profile: Wang Yiqing is a 2013 Nanjing Special-Term Professor, a board member of Jiangsu New Drug Development and Research Association, and an executive board member of Nanjing Medical Device Association. Since he started to work with Nanjing University’s Department of Biomedical Engineering in 2013, Wang and his research group have conducted research on precise navigation technology in tumor surgery with the strong support by Nie Shuming, dean of the college to which the faculty belongs. The research group has developed digital, intelligent and highly sensitive navigation devices with which development has been achieved in real time during the surgery as well as related tumor developer. It has been demonstrated by clinical results in many of Nanjing’s Grade-3 hospitals that devices of this kind can greatly help doctors completely remove malignant tumors in a surgery under the condition in which normal organ functions can be maximally maintained and patients’ after-surgery living quality can be guaranteed while the rate of survival in the first five years after tumor surgery can be increased. This technology has gained the recognition of Professor Sunil Singhal, an international authority in image navigation surgery and surgery expert in the Department of Thoracic Surgery, Affiliated Hospital of University of Pennsylvania. He even proposed to take part in the clinical experiment of this device in America, and Ni Kena, a graduate student in this research group has gone to the University of Pennsylvania to cooperate with Professor Singhal. The research group will send more students to America and strengthen this cooperation. Stanford University Professor William Moernar, a winner of 2014 Nobel Prize in Chemistry and an authority in molecular imaging, spoke highly of this technology when he came to Nanjing for an exchange. Currently, the research group is undertaking 1 key research project of the Ministry of Science and Technology and 3 Jiangsu Key Research and Development Projects (on cutting-edge clinical technology). Besides, the research group has made a great breakthrough in the development of new-type anti-cancer medicines and magnetic medical imaging nanomaterials. Professor Wang Yiqing was once a research assistant professor at the Department of Biomedical Engineering of Georgia Institute of Technology, Emory University, USA, and researched on nanotechnology in cancer chemotherapy and diagnosis under the supervision of Professor Nie Shuming. As a technical leader in the field of chemical and nanocarriers, he took part in several key scientific research projects supported by American National Cancer Institute such as Center of Nanotechnology Personalization and Predictable Tumor and Special Study on Head and Neck Cancer and developed a series of nano anti-cancer drugs with high scientific research value and great clinical application prospects. The research projects of this research group have reflected the engineering features of the Department of Modern Engineering and Applied Sciences by efficiently converting research outcomes into practical use and emphasizing fundamental research during scientific research conversion. Besides, this research group has published papers in first-class journals such as Analytical Chemistry and has applied for over 10 patents. Moreover, the research group has closely cooperated with several American research groups and therefore, there have been annual mutual visits and student exchange. Currently, the group consists of 2 full-time researchers and over 10 students and their research focuses include surgery navigation technologies, high-polymer chemistry, preparation of nano materials and their application in such areas as biology and medical science. Projects undertaken by this research group: 1. Research on and application of digital optical signals in the precise lymph node examination during a gastrointestinal tumor surgery, Jiangsu Key R&D Project (bulletin display over), July 2018 – July 2021, 2 million yuan, Wang in charge 2. Research and development of fluorescent molecule navigational surgery systems and their application in oral cancers, Jiangsu Key R&D Program (bulletin display over), July 2018 – July 2021, 2 million yuan, Wang in charge of a sub-project. 3. Translational research based on fluorescent molecular imaging guiding precise surgery for oral cancers, ZKX17032, Nanjing Key Scientific and Technological Development Project, May 2017 – December 2020, 200,000 yuan. On-going. Wang in charge of a sub-project. 4. Application of new-type molecular imaging tumor surgery guidance system in looking for metastatic lymph nodes, 021314380081, International Scientific and Technological Cooperation Promotion Project of Central Specific Fund for College Basic Scientific Research, January 2017 – December 2017, 200,000 yuan. Project finished. Wang in charge 5. New-generation highly sensitive and wide-field-of-view navigational system with multimodal molecular imaging in tumor surgeries, 2016YFC0104100, National Key R&D Project, July 2016 – December 2020, 10 million yuan. On-going. Wang in charge of a sub-project 6. Application of the technology of image guiding precise tumor surgery in gastrointestinal tumor surgeries, BE2016731, Jiangsu Key R&D Project (for social development), July 2016 – June 2019, 2 million yuan. On-going. Wang in charge of a sub-project. 7. 2016 “Jiangsu Innovative and Entrepreneurial Talent Program” 8. 2013 Jiangsu Special-Term Professor Research achievements: Papers (Note: * refers to corresponding author; # refers to equal contributor) (1) Wang, Ziyang,# Ni, Kena,#, Zhang, Xudong, Ai, Shichao, Guan, Wenxian, Cai, Huiming, Wang, Yiqing,* Lu, Qian, & Lane, Lucas A.* (2018). Method for real-time tissue quantification of Indocyanine green revealing optimal conditions for near infrared fluorescence guided surgery. Analytical Chemistry, 90(13), 7922-7929.
(2) Wang, Jianquan,# Lee, Gee Young, Lu, Qian, Peng, Xianghong, Wu, Jiangxiao, Wu, Siyuan, Kairdolf, Brad A, Nie, Shuming, Wang, Yiqing, & Lane, Lucas A. (2017). Quantitative examination of the active targeting effect: The key factor for maximal tumor accumulation and retention of short-circulated biopolymeric nanocarriers. Bioconjugate Chemistry, 28(5), 1351-1355.
(3) Quan, Li,# Wu, Jiangxiao, Lane, Lucas A, Wang, Jianquan, Lu, Qian, Gu, Zheng, & Wang, Yiqing.* (2016). Enhanced detection specificity and sensitivity of Alzheimer’s disease using Amyloid-β-Targeted quantum dots. Bioconjugate Chemistry, 27(3), 809-814.
(4) Wang, Jianquan,# Ma, Daoshuang, Lu, Qian, Wu, Shaoxiong, Lee, Gee Young, Lane, Lucas A, Li, Bin, Quan, Li, Wang, Yiqing,* & Nie, Shuming.* (2015). An unusual role of folate in the self-assembly of heparin–folate conjugates into nanoparticles. Nanoscale, 7(37), 15185-15190.
(5) Lee, Kate Y.J.,# Wang, Yiqing,* & Nie, Shuming. (2015). In vitro study of a pH-sensitive multifunctional doxorubicin–gold nanoparticle system: therapeutic effect and surface enhanced Raman scattering. RSC Advances, 5(81), 65651-65659.
(6) Quan, Li,# Liu, Shi, Sun, Tingting, Guan, Xingang, Lin, Wenhai, Xie, Zhigang, Huang, Yubin, Wang, Yiqing, & Jing, Xiabin.* (2014). Near-infrared emitting fluorescent BODIPY nanovesicles for in vivo molecular imaging and drug delivery. ACS applied materials & interfaces, 6(18), 16166-16173.
(7) Wang, Yiqing,# Lee, Gee Young, Yang, Lily, & Nie, Shuming.* (August 2012). Nanoformulated maytansinoid: Nanotechnology for rescuing previously failed cancer drugs. In ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY (Vol. 244). 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
(8) Song, Jie(#), Lee, Gee Young, Wang, Yiqing, Hill, Craig L., & Nie, Shuming(*). (2012, August). Polyoxometalates with different structures as novel inorganic drugs for cancer therapy. In Abstracts of Papers of the American Chemical Society (Vol. 244), 1155 16TH ST, NW, WASHINGTON, DC 20036 USA: AMER CHEMICAL SOC.
(9) Wang, Liqun,# Wang, Yiqing, & Ragauskas, Arthur J.* (2012). Determination of cellulase colocalization on cellulose fiber with quantitative FRET measured by acceptor photobleaching and spectrally unmixing fluorescence microscopy. Analyst, 137(6), 1319-1324.
(10) Peng, Xiang-Hong,# Wang, Yiqing,# Huang, Donghai, Wang, Yuxiang, Shin, Hyung Juc, Chen, Zhengjia, Spewak, Michael B, Mao, Hui, Wang, Xu, Wang, Ying, Chen, Zhuo Georgia, Shin, Dong M,* & Nie, Shuming.* (2011). Targeted delivery of cisplatin to lung cancer using ScFvEGFR-heparin-cisplatin nanoparticles. Acs Nano, 5(12), 9480-9493.
(11) Nduom, Edjah,# Machaidze, Revaz, Kaluzova, Milota, Wang, Yiqing, Nie, Shuming,* & Hadjipanayis, Costas.* (2010). ET-27. Convection Enhanced Delivery of maytansinoid nanoparticles for treatment of glioblastoma multiforme. Neuro-oncology, 12(suppl_4).
(12) Wang, Ying,# Wang, Yiqing,# Xiang, Jiannan, & Yao, Kaitai.* (2010). Target-specific cellular uptake of taxol-loaded heparin-PEG-folate nanoparticles. Biomacromolecules, 11(12), 3531-3538.
(13) Huang, Xiaohua,# Peng, Xianghong, Wang, Yiqing, Wang, Yuxiang, Shin, Dong M,* El-Sayed, Mostafa A,* & Nie, Shuming.* (2010). A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS nano, 4(10), 5887-5896.
(14) Wang, Liqun,# Wang, Yiqing, & Ragauskas, Arthur J.* (2010). A novel FRET approach for in situ investigation of cellulase–cellulose interaction. Analytical and bioanalytical chemistry, 398(3), 1257-1262.
2.Patents (1) Wang, Yiqing, Zhang, Xudong, Lu, Qian, Xie, Manman, Wang, Ziyang, Ni, Kena, He, Yilin, & Han, Jiuyuan. (2018). Method for establishment of tumor lymph node high-metastasis model and rapid fluorescence detection. Chinese Patent No. CN2018104402505.5. (2) Wang Yiqing,# Gu, Yixu, Xie, Manman, Wang, Jianquan, Lu, Qian, Zhang, Xudong, Ni, Kena, & Han, Jiuyuan. (2018). Heparin starch microsphere vascular embolizing agent with anti-tumor effect and preparation method thereof. Chinese Patent No. CN201810440203.0. (3) Wang, Yiqing,# Xie, Manman, Lu, Qian, Wang, Jianquan, Zhang, Xudong, Ni, Kena, & Gu, Yixu. (2017). Preparation method for single-layer coated water-soluble superparamagnetic ferroferric oxide nano-particle. Chinese Patent No. CN201710560157.3. (4) Wang, Yiqing,# Wang, Ziyang, Ni, Kena, & Cai, Huiming. (2017). Method of measuring distance and angle between laser probe and irradiated plane in real time using monitoring CCD. Chinese Patent No. CN201710413440.3. (5) Wang, Jianquan,# Lu, Qian, Wu, Jiangxiao, Cai, Huiming, & Wang, Yiqing.* (2017). Method for preparing antitumor pH-sensitive and non-pH-sensitive dextran-polylactic acid-polyethylene glycol nanoparticle drug delivery system. Chinese Patent No. CN201710130062.8. (6) Wang, Yiqing,# & Nie, Shuming. (2014). Nanoparticle for encapsulation and delivery of bioactive compounds and compositions thereof, American Patent No. WO2014201312. (7) Shin, M. Dong, Peng, Xianghong, Nie, Shuming, & Wang, Yiqing. (2013). Methods and compositions for treating cancer with platinum Particles. American Patent No. US20 130259944. Graduate students advisement: 1-2 doctoral students (including master-doctoral students) and 2-4 masters students are enrolled each year. The program welcomes those who are willing to be dedicated to the cause of human health! Please send email if you are interested: wangyiqing@nju.edu.cn Specialist cultivation and team building: Doctor Lu Qian was supported by Jiangsu Key R&D Project in 2018; Doctor Wang Jianquan was supported by the Nanjing University Cultivation Program of the National Natural Science Foundation (for youths) in 2018; Ai Shichao passed the Nanjing University doctoral qualification assessment in 2018 (ranking the first, and jointly cultivated by NJU and Gulou Hospital); Xie Manman was supported by Nanjing University Fund for Graduate Students Research and Innovation in 2017 (with 200,000 yuan); Doctor Lu Qian was supported by Nanjing Key Scientific and Technological Development Program in 2017; Doctor Lu Qian was supported by Nanjing University International Scientific and Technological Cooperation Promotion Program in 2017; Li Bin was supported by Nanjing University Doctoral Student Innovation and Creativity Program in 2016; Ni Kena was supported by Jiangsu Innovation Program for College Professional Degree Graduate Students in 2016; Ni Kena won the 1st prize of the Nanjing University Academic Scholarship in 2016; Wang Jianquan won the 2nd prize of 2015-2016 Nanjing University Guanghua Scholarship; Wang Jianquan was supported by Nanjing University Fund for Graduate Students Research and Innovation in 2015 (with 120,000 yuan); Doctor Lu Qian was supported by the Nanjing University Cultivation Program of the National Natural Science Foundation (for youths) in 2015.
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