DNA nanotechnology1. Rational Design and Programmable Self-Assembly of Higher-Order DNA NanostructuresThe continuous evolution of design principles is a key driving force in the advancement of DNA nanotechnology. Tailoring the design and assembly of self-assembled DNA nanostructures, guided by distinct research objectives, emerges as a pivotal pursuit within this realm. We focus on crafting design principles that facilitate the creation of advanced DNA assemblies extending beyond traditional frameworks. Our work addresses the limitations in the size and complexity of higher-order DNA origami assemblies and paves the way for user-defined, programmable patterning of molecules or materials across scales where new properties may arise.2. Tailored Engineering of Dynamic DNA NanodevicesBiological systems, characterized by their dynamic nature and complex behaviors in response to environmental cues, present a significant research focus across scientific domains. Leveraging the remarkable versatility and programmability of DNA, researchers aim to bridge the gap between biological complexity and synthetic precision. This emerging area of study focuses on the meticulous design and fabrication of DNA-based structures that can respond dynamically to external stimuli or environmental changes. We endeavor to elucidate the underlying principles governing dynamic behaviors in biological systems, and translate this knowledge into the development of highly functional and adaptable DNA nanodevices.3. Functionalized DNA Nanostructures for Biomedical ApplicationsThe development of nanomedicine is closely related to the evolution of nanocarriers that endow therapeutic agents with improved efficacy, safety, and specificity. A grand challenge in nanomedicine is the ability to design suitable nanocarriers that can precisely transport therapeutic agents across biological barriers in the complex environment of living organisms. The programmable and biocompatible nature of DNA has enabled the rational design of tailored DNA nanocarriers for targeted drug delivery which has greatly contributed to the remarkable progress in precision medicine. We focus on the development of multifunctional DNA nanoformulations targeting multifaceted disease mechanisms, with the aim of addressing the fundamental challenges in this domain.欢迎具有核酸纳米技术（结构/动态）、分子自组装、功能核酸、纳米医学等相关研究背景的同学联系。2026-2027年度计划招收直博生1-2名、硕士研究生1-2名、申请考核制博士研究生1-2名。

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