【生物医学工程论坛】6月8日美国哥伦比亚大学Kam W. Leong教授学术报告

发布者:钟芳发布时间:2017-05-31

    我们有幸邀请到Biomaterials主编,美国工程院院士,美国哥伦比亚大学生物医学工程系教授Kam W. Leong来访并分享学术报告。


报告题目:Bioengineering of Direct Cellular Reprogramming

时间:201768日上午1000

地点:鼓楼校区唐仲英楼B501

邀请人:魏辉 教授  weihui@nju.edu.cn

报告人简介:

Prof. Kam W. Leong is the Samuel Y. Sheng Professor of Biomedical Engineering at Columbia University. He received his PhD in Chemical Engineering from the University of Pennsylvania. After moving to Columbia University in September 2014, he continues to work on nanoparticle-mediated nonviral gene delivery and immunotherapy. The lab also works on the application of nanostructured biomaterials for regenerative medicine, particularly on understanding cell-topography interactions and on the application of nonviral vectors for direct cellular reprogramming and genome editing. He has published ~330 peer-reviewed research manuscripts with >35,000 citations, and holds more than 50 issued patents. Selected Publications have been published in the Nat. Med., Nat. Mate., PNAS, ACS Nano, Biomaterials, etc. (H-index=98)

报告摘要

Direct cell reprogramming or trans differentiation, where adult cells are reprogrammed from one lineage to another without going through an intermediate stem cell-like stage, produces cells promising for regenerative medicine. Prof. Kam W. Leong will discuss their recent efforts to convert human endothelial progenitors (hEPC) into induced smooth muscle cells (iSMC), hEPC into induced skeletal myocytes (iSkM), human fibroblasts into induced cardiomyocyte-like cells (iSML), and murine fibroblasts into induced neurons (iN). Meanwhile, he will describe various approaches of achieving direct cell reprogramming using transcription factor overexpression, microRNA delivery, molecular pathway manipulation, and CRISPR/dCas9-based transactivation either separately or in combination. This will be presented from the perspective of how biomaterials and biomedical engineering researchers can help advance this exciting field.








Professor

Biomaterials 主编,美国工程院院士